Curr Neuropharmacol. 2026 Mar 18. doi: 10.2174/011570159X425558260119114354. Online ahead of print.

ABSTRACT

INTRODUCTION/OBJECTIVE: Pharmacological treatments for Post-Traumatic Stress Disorder (PTSD), a disorder that affects emotions and mental health and is thought to be therapeutically deficient, either appear to have a number of adverse effects or cause patients to not take their medications as directed. The effectiveness of non-pharmacological treatments for PTSD-related anxiety, depression, and trauma-related discomfort is examined in the current systematic review.

METHODS: Fifty-five relevant studies that reported on the randomized controlled trials and metaanalyses published between 2008 and 2025 were found through a thorough search of a total of 12 databases. Mindfulness-Based Stress Reduction (MBSR), Cognitive Behavioral Therapy (CBT), Eye Movement Desensitization and Reprocessing (EMDR), laughter therapy, acupuncture, dietary modifications, and yoga are among the interventions of interest that were studied.

RESULTS: The severity of PTSD symptoms has been reported to be reliably reduced by MBSR, CBT, and EMDR; some trials of MBSR and CBT have shown improvements of up to 45%. Acupuncture, yoga, and laughter therapy all demonstrated positive impacts; the outcomes varied significantly. Dietary and lifestyle changes appeared to help stabilize mental health, but further research is needed.

DISCUSSION: Results highlight the benefits of non-pharmacological therapies as highly effective and preferable PTSD treatment options, especially for individuals who are sensitive to pharmacotherapy. The strongest, most reliable results were obtained by MBSR and CBT in particular, highlighting the significance of cognitive restructuring and present-moment concentration. While nutrition, yoga, acupuncture, and laughter therapy all contributed to stress alleviation or emotional regulation, EMDR was particularly effective at processing memories without the requirement for verbalization. These tactics encourage resilience, self-control, and empowerment, but future research must address methodological variation, sample size, and intervention standardization.

CONCLUSION: Non-pharmacological approaches offer promising complementary or standalone strategies for PTSD management. Further large-scale, standardized trials are warranted to strengthen the evidence base and optimize treatment protocols.

PMID:41863279 | DOI:10.2174/011570159X425558260119114354