The connection between the design and delivery of health care services using information technology is known as health informatics. It involves data usage, validation, and transfer of an integrated medical analysis using neural networks of multi-layer deep learning techniques to analyze complex data. For instance, Google incorporated ''DeepMind'' health mobile tool that integrates & leverage medical data needed to enhance professional healthcare delivery to patients. Moorfield Eye Hospital London introduced DeepMind Research Algorithms with dozens of retinal scans attributes while DeepMind UCL handled the identification of cancerous tissues using CT & MRI Scan tools. Atomise analyzed drugs and chemicals with Deep Learning Neural Networks to identify accurate pre-clinical prescriptions. Health informatics makes medical care intelligent, interactive, cost-effective, and accessible; especially with DL application tools for detecting the actual cause of diseases. The extensive use of neural network tools leads to the expansion of different medical disciplines which mitigates data complexity and enhances 3-4D overlap images using target point label data detectors that support data augmentation, un-semi-supervised learning, multi-modality and transfer learning architecture. Health science over the years focused on artificial intelligence tools for care delivery, chronic care management, prevention/wellness, clinical supports, and diagnosis. The outcome of their research leads to cardiac arrest diagnosis through Heart Signal Computer-Aided Diagnostic tool (CADX) and other multifunctional deep learning techniques that offer care, diagnosis & treatment. Health informatics provides monitored outcomes of human body organs through medical images that classify interstitial lung disease, detects image nodules for reconstruction & tumor segmentation. The emergent medical research applications gave rise to clinical-pathological human-level performing tools for handling Radiological, Ophthalmological, and Dental diagnosis. This research will evaluate methodologies, Deep learning architectures, approaches, bio-informatics, specified function requirements, monitoring tools, ANN (artificial neural network), data labeling & annotation algorithms that control data validation, modeling, and diagnosis of different diseases using smart monitoring health informatics applications. DOI:10.48550/arxiv.2208.03143