Comprendre coenzyme q10 agingCoenzyme q10 aging : crit Rev Food Sci Nutr. 2022 Oct 27:1-13. doi: 10.1080/10408398.2022.2137724. Online ahead of print. ABSTRACT Coenzyme Q10 (CoQ10) is an essential component of the electron transport chain. It also acts as an antioxidant in cellular membranes. It can be endogenously produced in all cells by a specialized mitochondrial pathway. CoQ10 deficiency, which can result from aging or insufficient enzyme function, has been considered to increase oxidative stress. Some drugs, including statins and bisphosphonates, often used by older individuals, can interfere with enzymes responsible for endogenous CoQ10 synthesis. Oral supplementation with high doses of CoQ10 can increase both Ce que disent les donnéesits circulating and intracellular levels and several clinical trials observed that its administration provided beneficial effects on different disorders such as cardiovascular disease and inflammation which have been associated with low CoQ10 levels and high oxidative stress. Moreover, CoQ10 has been suggested as a promising therapeutic agent to prevent and slow the progression of other diseases including metabolic syndrome and type 2 diabetes, neurodegenerative and male infertility. However, there is still a need for further studies and well-designed clinical trials involving a large number of participants undergoing longer treatments to assess the benefits of CoQ10 for these disorders. PMID:36300654 | DOI:10.1080/10408398.2022.2137724Points clés sur coenzyme q10 agingL'article « Coenzyme Q10 in aging and disease » aborde un sujet recherché par les professionnels de santé. Outre la lecture ci-dessus, il est utile de replacer coenzyme q10 aging dans le contexte global de l'alimentation thérapeutique : individualiser les apports, vérifier les interactions avec les traitements et documenter les objectifs avec le patient.Pour approfondir, croisez ces informations avec les recommandations HAS, les avis de la ANSES et les données cliniques récentes publiées sur le sujet.