Curr Protein Pept Sci. 2025 Jan 21. doi: 10.2174/0113892037340795241202044932. Online ahead of print.

ABSTRACT

INTRODUCTION: Diabetic nephropathy is characterized by elevated oxidative stress and chronic inflammation in the kidneys. A class of proteins called sirtuins is well-known to be important for a number of cellular functions, such as metabolism, stress tolerance, and ageing. Among them, SIRT1 is associated with the progression of diabetic nephropathy, a dangerous kidney-related consequence of diabetes mellitus. Thus, this study aims to examine the function and pathways of sirtuin that are responsible for the progression of this disease.

METHODS: Publications considered from the standard databases like PUBMED-MEDLINE, Google Scholar, and Scopus using standard keywords, « Sirtuin, » Signalling pathway », and « Diabetic Nephropathy » well described the actual knowledge on the scientific literature indicating patient susceptibility to kidney disease that is influenced by sirtuin-1 gene variants.

RESULTS: The research results imply that sirtuins offer enormous promise as cutting-edge therapeutic targets for kidney disease prevention and management. Renal fibrosis, metabolic disorders, renal impairment, and a possible regulation mechanism all probably entail blocking inflammation through various signalling pathways.

CONCLUSION: A comprehensive understanding of the fundamental pathophysiological pathways targeting sirtuin is essential as a diagnostic tool. For the treatment of diabetic nephropathy, researchers are developing therapeutic techniques to target biological roles and functions of different types of sirtuin, processes, and signalling pathways.

PMID:39844569 | DOI:10.2174/0113892037340795241202044932