Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity

Comprendre relationship between gutRelationship between gut : curr Med Chem. 2021;28(4):827-839. doi: 10.2174/0929867327666200721160313. ABSTRACT Intestinal hyperpermeability is a complex metabolic process mediated by different pathways in close relation to the gut microbiota. Previous studies suggested that the gut microbiota is involved in different metabolic regulations, and its imbalance is associated with several metabolic diseases, including obesity. It is well known that intestinal hyperpermeability is associated with dysbiosis, and the combination of these two conditions can lead to an increase in the level of low-grade inflammation in obese patients due to an increase in pro-inflammatory cytokine levels. Inflammatory bowel syndrome Ce que disent les donnéesoften accompanies this condition causing an alteration of the intestinal mucosa and thus reinforcing the dysbiosis and gut hyperpermeability. The onset of metabolic disorders depends on violations of the integrity of the intestinal barrier as a result of increased intestinal permeability. Chronic inflammation due to endotoxemia is responsible for the development of obesity. Metabolic disorders are associated with dysregulation of the microbiota-gut-brain axis and with an altered composition of gut flora. In this review, we will discuss the mechanisms that illustrate the relationship between hyperpermeability, the composition of the gut microbiota, and obesity. PMID:32693755 | DOI:10.2174/0929867327666200721160313Points clés sur relationship between gutL'article « Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity » aborde un sujet recherché par les professionnels de santé. Outre la lecture ci-dessus, il est utile de replacer relationship between gut dans le contexte global de l'alimentation thérapeutique : individualiser les apports, vérifier les interactions avec les traitements et documenter les objectifs avec le patient.Pour approfondir, croisez ces informations avec les recommandations HAS, les avis de la ANSES et les données cliniques récentes publiées sur le sujet.