Curr Protein Pept Sci. 2025 Aug 1. doi: 10.2174/0113892037368963250710184315. Online ahead of print.

ABSTRACT

INTRODUCTION: An endocrine condition known as Poly-Cystic Ovarian Syndrome (PCOS) makes females of reproductive age more susceptible to insulin resistance, excessive levels of male hormones, and delayed ovulation. It is the main reason that stimulates infertility in females during their reproductive years. Thus, the objective of the present research is to determine whether oleogum resins derived from Boswellia serrata and Commiphora myrrh could be beneficial in the treatment of PCOS using a female animal model (Wistar rats) that were administered 1 mg/ kg of letrozole for induction of the disease.

METHODS: A combination therapy of Boswellia serrata and Commiphora myrrh was used to study its effect on rat models administered letrozole (1mg/ kg), employed to induce PCOS. OECD Guidelines 407 and 423 were followed for toxicity studies.

RESULTS: It was revealed that the polyherbal mixture is nontoxic and safe to use, according to the results. Furthermore, studies have investigated the potential of a combination of oleo-gum resins in the treatment of letrozole-induced PCOS using animal models. According to the information gathered, it was found that the prepared herbal mixture significantly affected the letrozole-induced PCOS rat models. Additionally, it seems to have potential benefits for PCOS-related hormonal and reproductive disorders.

CONCLUSION: The polyherbal mixture was considered safe for consumption at a dose concentration of under 2000 mg/ kg and can be used for an extended period. Additionally, the polyherbal mixture improved the outcome of the therapy of PCOS in rat models administered with letrozole (1mg/ kg) employed to induce PCOS.

PMID:40760753 | DOI:10.2174/0113892037368963250710184315