Mol Nutr Food Res. 2025 Nov 6:e70308. doi: 10.1002/mnfr.70308. Online ahead of print.

ABSTRACT

The gut microbiota plays a vital role in the aging process and the onset of age-related diseases, offering promising targets for dietary interventions to support healthy aging. This diverse microbial community influences metabolism, immune function, and gut homeostasis, all of which are impacted by diet. Nutrients such as dietary fiber, polyphenols, plant-based proteins, and fermented foods promote beneficial microbes and metabolites like short-chain fatty acids (SCFAs), which help reduce inflammation and protect against chronic conditions, including cardiovascular disease, diabetes, and neurodegenerative disorders. However, aging is often accompanied by reduced microbial diversity and dysbiosis, contributing to chronic low-grade inflammation or, « inflammaging. » Dietary strategies incorporating prebiotics, probiotics, and postbiotics may help restore microbial balance and mitigate age-related decline. Despite advances, challenges remain in translating microbiota research to clinical practice due to individual variability, limited human trials, and issues of accessibility. This review highlights the potential of microbiota-focused diets in managing age-related diseases and promoting longevity.

PMID:41195914 | DOI:10.1002/mnfr.70308