Comprendre supplement combined supplementationSupplement combined supplementation : nutrients. 2022 Oct 19;14(20):4383. doi: 10.3390/nu14204383. ABSTRACT Coenzyme Q10 (CoQ10) is a compound with a crucial role in mitochondrial bioenergetics and membrane antioxidant protection. Despite the ubiquitous endogenous biosynthesis, specific medical conditions are associated with low circulating CoQ10 levels. However, previous studies of oral CoQ10 supplementation yielded inconsistent outcomes. In this article, we reviewed previous CoQ10 trials, either single or in combination with other nutrients, and stratified the study participants according to their metabolic statuses and medical conditions. The CoQ10 supplementation trials in elders reported many favorable outcomes. However, the single intervention was less promising when the host metabolic statuses were worsening Ce que disent les donnéeswith the likelihood of multiple nutrient insufficiencies, as in patients with an established diagnosis of metabolic or immune-related disorders. On the contrary, the mixed CoQ10 supplementation with other interacting nutrients created more promising impacts in hosts with compromised nutrient reserves. Furthermore, the results of either single or combined intervention will be less promising in far-advanced conditions with established damage, such as neurodegenerative disorders or cancers. With the limited high-level evidence studies on each host metabolic category, we could only conclude that the considerations of whether to take supplementation varied by the individuals' metabolic status and their nutrient reserves. Further studies are warranted. PMID:36297067 | PMC:PMC9609170 | DOI:10.3390/nu14204383Points clés sur supplement combined supplementationL'article « Combined Supplementation of Coenzyme Q10 and Other Nutrients in Specific Medical Conditions » aborde un sujet recherché par les professionnels de santé. Outre la lecture ci-dessus, il est utile de replacer supplement combined supplementation dans le contexte global de l'alimentation thérapeutique : individualiser les apports, vérifier les interactions avec les traitements et documenter les objectifs avec le patient.Pour approfondir, croisez ces informations avec les recommandations HAS, les avis de la ANSES et les données cliniques récentes publiées sur le sujet.