vendredi, septembre 5, 2025
Aucun résultat
Voir tous les résultats
Newsletter
  • Accueil
  • Articles
  • Articles de recherche
  • Réservez une consultationProfitez
  • Accueil
  • Articles
  • Articles de recherche
  • Réservez une consultationProfitez
Aucun résultat
Voir tous les résultats
OrthoDiet
Aucun résultat
Voir tous les résultats

These days, a lot of people are looking for reliable ways to get antibiotics when they need them. If you’re considering treatment, you might find it helpful to order Keflex online in Malaysia. It’s convenient, but always make sure you’re using a trusted pharmacy and, ideally, check in with your doctor before starting any new medication.

Therapeutic Targets for Myocardial Fibrosis: A Comprehensive Review of Current and Emerging Approaches

Cardiovasc Hematol Disord Drug Targets. 2025 Sep 2. doi: 10.2174/011871529X365096250827101044. Online ahead of print.

ABSTRACT

INTRODUCTION: Cardiovascular disorders (CVDs) remain the leading cause of global mortality, surpassing other chronic illnesses. An alarming rise in CVD-related deaths, particularly among younger populations, has intensified research efforts to better understand the disease and its complications. Among these, myocardial fibrosis plays a central role in the development of cardiac dysfunction and heart failure. Given its multifactorial nature, diverse therapeutic strategies are required to manage its progression effectively.

METHODS: A comprehensive literature review was conducted using databases such as PubMed, Scopus, Elsevier, and ClinicalTrials.gov. Only peer-reviewed, English-language studies focusing on molecular mechanisms and therapeutic strategies for myocardial fibrosis were included. Irrelevant, non-English, and non-peer-reviewed sources were excluded. Data from selected preclinical and clinical investigations were qualitatively synthesized.

RESULTS: Myocardial fibrosis arises from various pathological conditions, including ischemia, hyperlipidemia, and genetic disorders, which promote maladaptive cardiac remodeling. Although traditional treatments such as RAAS inhibitors and β-blockers offer symptomatic relief, they do not halt disease progression. Recent evidence suggests that multiple molecular pathways are involved in the development of fibrosis, opening opportunities to explore alternative therapeutic targets.

DISCUSSION: Due to its complex pathophysiology, myocardial fibrosis cannot be addressed by monotherapy alone. Anti-TGF-β agents have emerged as promising candidates, alongside newer therapies like SGLT2 inhibitors and MMP inhibitors. Additionally, regenerative approaches, such as stem cell and gene therapy, offer future avenues, though technical and safety challenges accompany them.

CONCLUSION: Myocardial fibrosis remains a critical contributor to heart failure, and current treatments are insufficient to reverse its course. A multifaceted therapeutic approach targeting different molecular mechanisms holds the key to improved clinical outcomes. Continued translational research is crucial for advancing emerging therapies from bench to bedside.

PMID:40908522 | DOI:10.2174/011871529X365096250827101044

Partager :

  • Facebook
  • X

J’aime ça :

J’aime chargement…

Articles similaires

Congrès Microbiome 360°

11-12 Octobre 2025 • Lyon

S'inscrire

Laisser un commentaire Annuler la réponse

Votre adresse e-mail ne sera pas publiée. Les champs obligatoires sont indiqués avec *

MES ARTICLES DE RECHERCHE

Tailored Therapies for Hereditary Diabetes: Unraveling the Genetic Underpinnings of MODY and Neonatal Diabetes

Therapeutic Targets for Myocardial Fibrosis: A Comprehensive Review of Current and Emerging Approaches

Pharmacological Evaluation of the Combination Therapy of Novel Herbal Mixture in Polycystic Ovary Syndrome

Congrès Microbiome 360°

NEURO-DIGESTION

11-12 Octobre 2025 • Lyon, France

THÉMATIQUE PRINCIPALE

Approche globale du syndrome de l'intestin irritable et du SIBO

POINTS CLÉS DU CONGRÈS

  • ✓ Accès à toutes les conférences
  • ✓ Intervenants internationaux de renom
  • ✓ Traduction simultanée disponible
  • ✓ Accès aux replays pendant 6 mois

CODE PROMO -20%

PROMO20

Offre valable jusqu'au 18 Mars 2025

Pass Présentiel

325€ TTC

Pass Virtuel

275€ TTC

Je m'inscris en présentiel Je m'inscris en ligne

Pour plus d'informations :

Email : secretariat@orthodiet.org

Tél : +33 6 46 55 80 69

L'Embarcadère Réservoir d'évènements 13 Bis Quai Rambaud, 69002 Lyon, France

PUBLICITÉ

© 2024 OrthoDiet - Owned by A&A Health S.A.S SIREN: 912674660 - France

Aucun résultat
Voir tous les résultats
  • Home
  • Articles
  • Articles de recherche
  • Réservez une consultation avec Dr Amin Gasmi
  • Formation Auto-Immunité 2024
  • Formation Maladies Intestinales & Micronutrition

© 2024 OrthoDiet - Owned by A&A Health S.A.S SIREN: 912674660 - France

Bienvenue de retour !

Connectez-vous à votre compte ci-dessous

Mot de Passe Oublié ?

Récupérer votre mot de passe

Veuillez entrer votre nom d'utilisateur ou votre adresse e-mail pour réinitialiser votre mot de passe.

Se Connecter

Ajouter une nouvelle playlist

Ce site web utilise des cookies. En continuant à utiliser ce site web, vous consentez à ce que des cookies soient utilisés.
%d