Mes articles scientifiques

  • Genetic and Epigenetic Determinants of COVID-19 Susceptibility: A Systematic Review
    par Amin Gasmi le 22 janvier 2024 à 11:00

    CONCLUSION: There is a notable absence of research into the gender-related predisposition to infection, necessitating a thorough examination. According to the available literature, a significant portion of individuals affected by the ailment or displaying severe ramifications already had suppressed immune systems, categorizing them as a group with elevated risk.

  • The Possible Roles of β-alanine and L-carnosine in Anti-aging
    par Amin Gasmi le 20 janvier 2024 à 11:00

    alanine (BA), being a non-proteinogenic amino acid, is an important constituent of L-carnosine (LC), which is necessary for maintaining the muscle buffering capacity and preventing a loss of muscle mass associated with aging effects. BA is also very important for normal human metabolism due to the formation of a part of pantothenate, which is incorporated into coenzyme A. BA is synthesized in the liver, and its combination with histidine results in the formation of LC, which accumulates in the…

  • An Update on Glutathione’s Biosynthesis, Metabolism, Functions, and Medicinal Purposes
    par Amin Gasmi le 3 novembre 2023 à 10:00

    Glutathione (GSH) has been the focus of increased scientific interest in the last decades. It plays a crucial role in all major physiological processes by supplying antioxidant defenses through participating in cellular redox reactions in the human body and other living organisms. GSH also participates in detoxifying xenobiotics, protecting protein thiols from crosslinking and oxidation, regulating the cell cycle, storing cysteine, etc. The significant role of GSH in the most important…

  • Potential drugs in COVID-19 management
    par Amin Gasmi le 18 juillet 2023 à 10:00

    The SARS-CoV-2 virus first emerged in China in December 2019 and quickly spread worldwide. Despite the absence of a vaccination or authorized drug specifically developed to combat this infection, certain medications recommended for other diseases have shown potential effectiveness in treating COVID-19, although without definitive confirmation. This review aims to evaluate the existing literature on the efficacy of these medications against COVID-19. The review encompasses various potential…

  • Natural Compounds Used for Treating Hair Loss
    par Amin Gasmi le 8 mai 2023 à 10:00

    Hair loss or alopecia is a common dermatological condition affecting up to 2% of the world population. It is often caused by hereditary factors, such as male or female pattern baldness, but it can also result from various environmental factors, an unbalanced diet, or chronic illness. While hair loss is not life-threatening, it can cause significant anxiety, depression, and other psychological problems, ultimately impacting an individual’s quality of life. Various treatments for hair loss,…

  • Pharmacological Treatments and Natural Biocompounds in Weight Management
    par Amin Gasmi le 4 mai 2023 à 10:00

    The obesity pandemic is one of society’s most urgent public health concerns. One-third of the global adult population may fall under obese or overweight by 2025, suggesting a rising demand for medical care and an exorbitant cost of healthcare expenditure in the coming years. Generally, the treatment strategy for obese patients is largely patient-centric and needs dietary, behavioral, pharmacological, and sometimes even surgical interventions. Given that obesity cases are rising in adults and…

  • Anticancer activity of broccoli, its organosulfur and polyphenolic compounds
    par Amin Gasmi le 2 mai 2023 à 10:00

    The use of natural bioactive constituents from various food sources for anticancer purposes has become increasingly popular worldwide. Broccoli (Brassica oleracea var. italica) is on the top of the consumed vegetables by the masses. Its raw matrix contains a plethora of phytochemicals, such as glucosinolates and phenolic compounds, along with rich amounts of vitamins, and minerals. Consumption of broccoli-derived phytochemicals provides strong antioxidant effects, particularly due to its…

  • Natural Ingredients to Improve Immunity
    par Amin Gasmi le 28 avril 2023 à 10:00

    The immune system protects the body from infectious agents such as bacteria, viruses, or fungi. Once encountered with pathogens or antigens, the innate and adaptive arms of the immune system trigger a strong immune response to eliminate them from the system and protect the body. Thus, well-balanced immunity is pivotal for maintaining human health, as an insufficient level of immune defense leads to infections and tumors. In contrast, the excessive functioning of the immune system causes the…

  • Traditional Chinese Medicine as the preventive and therapeutic remedy for COVID-19
    par Amin Gasmi le 31 mars 2023 à 10:00

    The coronavirus disease 2019 (COVID-19) pandemic still has tremendous impacts on the global socio-economy and quality of living. The traditional Chinese Medicines (TCM) approach showed encouraging results during previous outbreaks of Severe Acute Respiratory Syndrome-related coronavirus (SARS-CoV) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). With limited treatment availability, TCM herbs and formulations could be viable to reduce COVID-19 symptoms and potential sources for…

  • Coenzyme Q10 for enhancing physical activity and extending the human life cycle
    par Geir Bjørklund le 28 février 2023 à 11:00

    CONCLUSION: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.

  • Sleep, Dietary Melatonin Supplementation, and COVID-19
    par Amin Gasmi le 24 février 2023 à 11:00

    CONCLUSION: In patients admitted to intensive care units, melatonin decreases the risks of severe complications, such as thrombosis and sepsis, and mortality rates. In addition, it is efficacious in lowering vessel permeability, depression, and sedation, and improving the quality of sleep, which could also help COVID-19 patients achieve better clinical outcomes.

  • Berberine: Pharmacological Features in Health, Disease and Aging
    par Amin Gasmi le 7 février 2023 à 11:00

    CONCLUSION: Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has provided a basis for scientists to establish clinical trials in humans. However, for obesity, the evidence appears to be sufficient for hands-on use.

  • Metabolic Conditions and Peri-Implantitis
    par Asma Gasmi Benahmed le 21 janvier 2023 à 11:00

    Dental implants to replace lost teeth are a common dentistry practice nowadays. Titanium dental implants display a high success rate and improved safety profile. Nevertheless, there is an increasing peri-implantitis (PI), an inflammatory disease associated with polymicrobial infection that adversely affects the hard and soft tissues around the implant. The present review highlights the contribution of different metabolic conditions to PI. The considerations of both local and systemic metabolic…

  • Neurotransmitters Regulation and Food Intake: The Role of Dietary Sources in Neurotransmission
    par Amin Gasmi le 8 janvier 2023 à 11:00

    Neurotransmitters (NTs) are biologically active chemicals, which mediate the electrochemical transmission between neurons. NTs control numerous organic functions particularly crucial for life, including movement, emotional responses, and the physical ability to feel pleasure and pain. These molecules are synthesized from simple, very common precursors. Many types of NTs have both excitatory and inhibitory effects. Neurotransmitters’ imbalance can cause many diseases and disorders, such as…

  • The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions
    par Geir Bjørklund le 11 novembre 2022 à 11:00

    The current review provides an up-to-date analysis of scientific data on astaxanthin (ASX) sources and experimental studies on its health benefits as a potent antioxidant in the aging process. ASX is a liposoluble carotenoid nutrient and reddish-orange pigment, naturally synthesized by numerous microalgae, yeasts, and bacteria as secondary metabolites. Provides a reddish hue to redfish and shellfish flesh that feed on ASX-producing microorganisms. The microalga Haematococcus pluvialis is the…

  • Combined Supplementation of Coenzyme Q10 and Other Nutrients in Specific Medical Conditions
    par Torsak Tippairote le 27 octobre 2022 à 10:00

    Coenzyme Q(10) (CoQ(10)) is a compound with a crucial role in mitochondrial bioenergetics and membrane antioxidant protection. Despite the ubiquitous endogenous biosynthesis, specific medical conditions are associated with low circulating CoQ(10) levels. However, previous studies of oral CoQ(10) supplementation yielded inconsistent outcomes. In this article, we reviewed previous CoQ(10) trials, either single or in combination with other nutrients, and stratified the study participants according…

  • Coenzyme Q10 in aging and disease
    par Amin Gasmi le 27 octobre 2022 à 10:00

    Coenzyme Q(10) (CoQ(10)) is an essential component of the electron transport chain. It also acts as an antioxidant in cellular membranes. It can be endogenously produced in all cells by a specialized mitochondrial pathway. CoQ(10) deficiency, which can result from aging or insufficient enzyme function, has been considered to increase oxidative stress. Some drugs, including statins and bisphosphonates, often used by older individuals, can interfere with enzymes responsible for endogenous CoQ(10)…

  • Polyphenols in Metabolic Diseases
    par Amin Gasmi le 14 octobre 2022 à 10:00

    Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo and in vitro, as well as reported clinical studies. Considering their free-radical scavenging and anti-inflammatory properties, these substances can be used to treat different kinds of conditions associated with metabolic disorders. Many symptoms of metabolic syndrome…

  • Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2
    par Amin Gasmi le 23 septembre 2022 à 10:00

    The COVID-19 outbreak seems to be the most dangerous challenge of the third millennium due to its highly contagious nature. Amongst natural molecules for COVID-19 treatment, the flavonoid molecule quercetin (QR) is currently considered one of the most promising. QR is an active agent against SARS and MERS due to its antimicrobial, antiviral, anti-inflammatory, antioxidant, and some other beneficial effects. QR may hold therapeutic potential against SARS-CoV-2 due to its inhibitory effects on…

  • Gut microbiota in bariatric surgery
    par Amin Gasmi le 9 mai 2022 à 10:00

    Gut microbes share a symbiotic relationship with humans and perform several metabolic and physiological functions essential for human survival. It has been established in several scientific studies that obesity and other metabolic complications are always associated with disturbed gut microbiota profile, also called gut dysbiosis. In recent years, bariatric surgery has become a treatment of choice for weight loss, and it forms an important part of obesity management strategies across the globe….

  • Physical activity and obesity spectrum disorders in post-bariatric surgery patients: A systematic review and Meta-analysis
    par Amin Gasmi le 20 avril 2022 à 10:00

    CONCLUSION: BMI as a measure of physical activity positively impacts the target population. Large-scale studies with better criteria and a longer evaluation follow-up may finalize pronounced outcomes.

  • Dietary supplements and bariatric surgery
    par Amin Gasmi le 15 avril 2022 à 10:00

    Bariatric surgery or weight loss surgery has been in practice for achieving significant weight loss in patients who have failed to achieve weight loss after pharmacological interventions. The rising cases of obesity are a triggering factor for more bariatric surgeries worldwide. Interestingly, sustained weight loss achieved post-bariatric surgery offers metabolic advantages, and patients show improved glucose and lipid metabolisms. Bariatric surgery is directly linked to higher incidences of…

  • A global survey in the developmental landscape of possible vaccination strategies for COVID-19
    par Amin Gasmi le 26 février 2022 à 11:00

    The development of COVID-19 vaccines was promptly regulated to ensure the best possible approach. By January 2022, 75 candidates reached preclinical evaluation in various animal models, 114 vaccines were in clinical trials on humans, and 48 were in the final testing stages. Vaccine platforms range from whole virus vaccines to nucleic acid vaccines, which are the most promising in prompt availability and safety. The USA and Europe have approved vaccines developed by Pfizer-BioNTech (BNT162b2) and…

  • Improving safety in dental practices during the COVID-19 pandemic
    par Asma Gasmi Benahmed le 17 janvier 2022 à 11:00

    Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It originated from the Chinese city of Wuhan and very quickly became a challenging public health problem. On 11 March 2020, the World Health Organization termed this potentially deadly disease a pandemic due to its rapid spread in various parts of the world, giving rise to international health emergencies. This virus is transmitted from human to human in…

  • Nutritional and surgical aspects in prostate disorders
    par Amin Gasmi le 13 janvier 2022 à 11:00

    Prostate disorders are commonplace in medicine, especially in older men, with prostatitis, benign prostatic hyperplasia, and prostate cancer being the most abundant pathologies. The complexity of this organ, however, turns treatment into a challenge. In this review, we aim to provide insight into the efficacy of alternative treatments, which are not normally used in conventional medicine, with a particular focus on nutrients. In order to understand why and how nutrition can be beneficial in…

  • A review on natural teeth whitening
    par Asma Gasmi Benahmed le 16 décembre 2021 à 11:00

    CONCLUSION: Natural teeth whitening effectively lightens the natural color of teeth without eroding dental surfaces. On the other hand, commercially available whiteners containing hydrogen peroxide and carbamide peroxide, in high concentrations, can lead to deproteinization and demineralization of teeth through oxidation processes. If used extensively, these compounds may cause a number of adverse effects. Alternative natural teeth-whiteners include ingredients like lemons, strawberries,…

  • Micronutrients deficiences in patients after bariatric surgery
    par Amin Gasmi le 24 juillet 2021 à 10:00

    Bariatric surgery is an effective option for managing obesity and has gained general acceptance among patients in recent years. Generally, despite the high caloric intake, a bad nutritional habit of obese people results in the deficiency of several vitamins, minerals, and trace elements essential for body metabolism and normal physiological processes. Additionally, the current bariatric surgical approaches such as sleeve gastrectomy (SG), Roux-en-Y-gastric bypass (RYGB), laparoscopic adjustable…

  • Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation
    par Amin Gasmi le 10 mai 2021 à 10:00

    Calcium is involved in bone metabolism, regulation of nerve signaling, and release of neurotransmitters. Phosphorus is a structural component of ATP, participates in metabolic energy regulation, and ensures stability to biological membranes and cells. Vitamin D and vitamin K are important for intestinal absorption and renal excretion of calcium and phosphorus. Vitamin D plays a regulatory role in bone formation, carbohydrate metabolism, immune responses, and cardiovascular regulation. Research…

  • The microbiota-mediated dietary and nutritional interventions for COVID-19
    par Amin Gasmi le 12 avril 2021 à 10:00

    Worldwide, scientists are looking for specific treatment for COVID-19. Apart from the antiviral approach, the interventions to support healthy immune responses to the virus are feasible through diet, nutrition, and lifestyle approaches. This narrative review explores the recent studies on dietary, nutritional, and lifestyle interventions that influence the microbiota-mediated immunomodulatory effects against viral infections. Cumulative studies reported that the airway microbiota and SARS-CoV-2…

  • Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis
    par Amin Gasmi le 2 mars 2021 à 11:00

    A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate of glucose consumption in a cancer cell can be 10-15 times higher than in normal cells. Isolation and cultivation of tumor cells in vitro highlight properties that are associated with intensive glucose utilization, the presence of minimal oxidative metabolism, an increase in lactate concentrations in the culture medium and a reduced rate of oxygen consumption. Although glycolysis is suggested as a general…

  • The Role of Diet and Supplementation of Natural Products in COVID-19 Prevention
    par Amin Gasmi le 25 février 2021 à 11:00

    Recently, a discussion has begun on the global management strategy against COVID-19 based on the hypothesis that individuals’ macro- and micronutrient status combined with antiviral drugs and herbs can be an ally against the infection. The hypothesis is that people’s nutritional and oxidative scavenging capacity may provide fundamental data to predict severe and acute pulmonary distress following SARS-Cov2 infection. Consequently, the scientific community has addressed the role of balanced…

  • Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story
    par Amin Gasmi le 30 janvier 2021 à 11:00

    The anti-malarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been suggested as promising agents against the new coronavirus SARS-CoV-2 that induces COVID-19 and as a possible therapy for shortening the duration of the viral disease. The antiviral effects of CQ and HCQ have been demonstrated in vitro due to their ability to block viruses like coronavirus SARS in cell culture. CQ and HCQ have been proposed to reduce immune reactions to infectious agents, inhibit pneumonia…

  • The role of sugar-rich diet and salivary proteins in dental plaque formation and oral health
    par Asma Gasmi Benahmed le 26 janvier 2021 à 11:00

    CONCLUSION: The oral microbiota is essential for maintaining and reestablishing a healthy oral cavity. Different types of sugars have different effects on the inhibition and formation of dental plaque. The peptides, proteins, and amino acids secreted by parotid glands in the oral cavity facilitate neutralizing the acidity in dental plaque and preventing dental caries. A properly balanced diet is crucial for both a healthy oral cavity and the oral microbiome.

  • Interrelations between COVID-19 and other disorders
    par Amin Gasmi le 17 décembre 2020 à 11:00

    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory tract virus that causes Coronavirus disease (COVID-19). The virus originated in Wuhan, China, in December 2019 and has spread across the globe to-date. The disease ranges from asymptomatic carriers to symptoms such as fever, sore throat, cough, lung infections, and in severe cases, acute respiratory distress syndrome, sepsis, and death. As many as 50% of patients reported having at least one comorbidities with…

  • Neurological Involvements of SARS-CoV2 Infection
    par Amin Gasmi le 16 octobre 2020 à 10:00

    COVID-19 is a pandemic viral infection caused by a novel coronavirus, SARS-CoV2, which is a global concern of the twenty-first century for its rapid spreading in a short period. Apart from its known acute respiratory involvements, the CNS manifestations of COVID-19 are common. These neurological symptoms are diverse and could range from mild nonspecific or specific symptoms such as the loss of various sensory perceptions, the worrying autoimmune Guillain-Barré syndrome, to the life-threatening…

  • Biomarkers of Senescence during Aging as Possible Warnings to Use Preventive Measures
    par Amin Gasmi le 18 septembre 2020 à 10:00

    Human life expectancy is increasing significantly over time thanks to the improved possibility for people to take care of themselves and the higher availability of food, drugs, hygiene, services, and assistance. The increase in the average age of the population worldwide is, however, becoming a real concern, since aging is associated with the rapid increase in chronic inflammatory pathologies and degenerative diseases, very frequently dependent on senescent phenomena that occur alongside with…

  • Obesity and Insulin Resistance: Associations with Chronic Inflammation, Genetic and Epigenetic Factors
    par Amin Gasmi le 26 août 2020 à 10:00

    CONCLUSION: The purpose of the present review is an analysis of the multiple factors associated with obesity.

  • Association between the gut and oral microbiome with obesity
    par Asma Gasmi Benahmed le 18 août 2020 à 10:00

    In recent decades, obesity has become one of the most common lifestyle-associated disorders. Obesity is a major contributing factor for several other lifestyles associated disorders such as type 2 diabetes mellitus, hypertension, and cardiovascular disease. Although genetics and lifestyle have been directly implicated in the onset and progression of obesity, recent studies have established that gut microbiome plays a crucial role in obesity progression. A higher proportion of Firmicutes and a…

  • Micronutrients as immunomodulatory tools for COVID-19 management
    par Amin Gasmi le 26 juillet 2020 à 10:00

    COVID-19 rapidly turned to a global pandemic posing lethal threats to overwhelming health care capabilities, despite its relatively low mortality rate. The clinical respiratory symptoms include dry cough, fever, anosmia, breathing difficulties, and subsequent respiratory failure. No known cure is available for COVID-19. Apart from the anti-viral strategy, the supports of immune effectors and modulation of immunosuppressive mechanisms is the rationale immunomodulation approach in COVID-19…

  • Relationship between Gut Microbiota, Gut Hyperpermeability and Obesity
    par Amin Gasmi le 23 juillet 2020 à 10:00

    Intestinal hyperpermeability is a complex metabolic process mediated by different pathways in close relation to the gut microbiota. Previous studies suggested that the gut microbiota is involved in different metabolic regulations, and its imbalance is associated with several metabolic diseases, including obesity. It is well known that intestinal hyperpermeability is associated with dysbiosis, and the combination of these two conditions can lead to an increase in the level of low-grade…

  • Health benefits of xylitol
    par Asma Gasmi Benahmed le 9 juillet 2020 à 10:00

    Many diseases, including caries, chronic inflammatory diseases, diabetes, and obesity, are associated with uncontrolled sugar consumption. Artificial sweeteners are commonly used in food and pharmaceutical industries as sugar substitutes for the prevention of several dental and body diseases; they also have a favorable impact on body weight as they may help to restrict simple sugar consumption. Xylitol is a sugar alcohol that is commonly used as a sweetener. It can be found naturally or…

  • Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic
    par Amin Gasmi le 11 avril 2020 à 10:00

    It is an ugly fact that a significant amount of the world’s population will contract SARS-CoV-II infection with the current spreading. While a specific treatment is not yet coming soon, individual risk assessment and management strategies are crucial. The individual preventive and protective measures drive the personal risk of getting the disease. Among the virus-contracted hosts, their different metabolic status, as determined by their diet, nutrition, age, sex, medical conditions, lifestyle,…

  • Calanus oil in the treatment of obesity-related low-grade inflammation, insulin resistance, and atherosclerosis
    par Amin Gasmi le 20 décembre 2019 à 11:00

    Calanus oil (COil) is a natural product extracted from marine zooplankton Calanus finmarchicus found in the North Atlantic Ocean. This oil is rich in wax esters of polyunsaturated fatty acids (PUFAs) and has been projected as the best alternative to fish oil because its production cannot keep pace with the demands from the growing markets. The COil is the only commercially available marine source of wax esters, whereas classic ω-3 PUFAs comes from triglycerides, ethyl esters, and phospholipids….